A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

Cell fate decisions occur through the switch-like, irreversible activation of fate-specifying genes. These activation events are often assumed to be tightly coupled to changes in upstream transcription factors, but could also be constrained by cis-epigenetic mechanisms at individual gene loci. Here,...

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Detalles Bibliográficos
Autores principales: Ng, Kenneth KH, Yui, Mary A, Mehta, Arnav, Siu, Sharmayne, Irwin, Blythe, Pease, Shirley, Hirose, Satoshi, Elowitz, Michael B, Rothenberg, Ellen V, Kueh, Hao Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245732/
https://www.ncbi.nlm.nih.gov/pubmed/30457103
http://dx.doi.org/10.7554/eLife.37851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245732/
https://www.ncbi.nlm.nih.gov/pubmed/30457103
http://dx.doi.org/10.7554/eLife.37851

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