Active full-length DNA Aβ(42) immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology

BACKGROUND: Alzheimer’s disease (AD) is the most well-known and most common type of age-related dementia. Amyloid deposition and hyperphosphorylation of tau protein are both pathological hallmarks of AD. Using a triple-transgenic mouse model (3xTg-AD) that develops plaques and tangles in the brain s...

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Detalles Bibliográficos
Autores principales: Rosenberg, Roger N., Fu, Min, Lambracht-Washington, Doris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245829/
https://www.ncbi.nlm.nih.gov/pubmed/30454039
http://dx.doi.org/10.1186/s13195-018-0441-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245829/
https://www.ncbi.nlm.nih.gov/pubmed/30454039
http://dx.doi.org/10.1186/s13195-018-0441-4

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