KMgene: a unified R package for gene-based association analysis for complex traits

SUMMARY: In this report, we introduce an R package KMgene for performing gene-based association tests for familial, multivariate or longitudinal traits using kernel machine (KM) regression under a generalized linear mixed model framework. Extensive simulations were performed to evaluate the validity...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Qi, Fang, Zhou, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246171/
https://www.ncbi.nlm.nih.gov/pubmed/29438558
http://dx.doi.org/10.1093/bioinformatics/bty066
_version_ 1783372357924028416
author Yan, Qi
Fang, Zhou
Chen, Wei
author_facet Yan, Qi
Fang, Zhou
Chen, Wei
author_sort Yan, Qi
collection PubMed
description SUMMARY: In this report, we introduce an R package KMgene for performing gene-based association tests for familial, multivariate or longitudinal traits using kernel machine (KM) regression under a generalized linear mixed model framework. Extensive simulations were performed to evaluate the validity of the approaches implemented in KMgene. AVAILABILITY AND IMPLEMENTATION: http://cran.r-project.org/web/packages/KMgene. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
format Online
Article
Text
id pubmed-6246171
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-62461712018-11-27 KMgene: a unified R package for gene-based association analysis for complex traits Yan, Qi Fang, Zhou Chen, Wei Bioinformatics Applications Notes SUMMARY: In this report, we introduce an R package KMgene for performing gene-based association tests for familial, multivariate or longitudinal traits using kernel machine (KM) regression under a generalized linear mixed model framework. Extensive simulations were performed to evaluate the validity of the approaches implemented in KMgene. AVAILABILITY AND IMPLEMENTATION: http://cran.r-project.org/web/packages/KMgene. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. Oxford University Press 2018-06-15 2018-02-09 /pmc/articles/PMC6246171/ /pubmed/29438558 http://dx.doi.org/10.1093/bioinformatics/bty066 Text en © The Author(s) 2018. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Applications Notes
Yan, Qi
Fang, Zhou
Chen, Wei
KMgene: a unified R package for gene-based association analysis for complex traits
title KMgene: a unified R package for gene-based association analysis for complex traits
title_full KMgene: a unified R package for gene-based association analysis for complex traits
title_fullStr KMgene: a unified R package for gene-based association analysis for complex traits
title_full_unstemmed KMgene: a unified R package for gene-based association analysis for complex traits
title_short KMgene: a unified R package for gene-based association analysis for complex traits
title_sort kmgene: a unified r package for gene-based association analysis for complex traits
topic Applications Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246171/
https://www.ncbi.nlm.nih.gov/pubmed/29438558
http://dx.doi.org/10.1093/bioinformatics/bty066
work_keys_str_mv AT yanqi kmgeneaunifiedrpackageforgenebasedassociationanalysisforcomplextraits
AT fangzhou kmgeneaunifiedrpackageforgenebasedassociationanalysisforcomplextraits
AT chenwei kmgeneaunifiedrpackageforgenebasedassociationanalysisforcomplextraits

Ejemplares similares