Novel AR-12 derivatives, P12-23 and P12-34, inhibit flavivirus replication by blocking host de novo pyrimidine biosynthesis

The genus Flavivirus contains many important pathogens, including dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV). AR-12 is a celecoxib-derived anticancer agent that possesses antiviral activity against a broad range of viruses. We pharmacologically exploited this uniqu...

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Detalles Bibliográficos
Autores principales: Yang, Chao-Fu, Gopula, Balraj, Liang, Jian-Jong, Li, Jin-Kun, Chen, Si-Yu, Lee, Yi-Ling, Chen, Ching S., Lin, Yi-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246607/
https://www.ncbi.nlm.nih.gov/pubmed/30459406
http://dx.doi.org/10.1038/s41426-018-0191-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246607/
https://www.ncbi.nlm.nih.gov/pubmed/30459406
http://dx.doi.org/10.1038/s41426-018-0191-1

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