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The Mechanism behind Bacterial Lipoprotein Release: Phenol-Soluble Modulins Mediate Toll-Like Receptor 2 Activation via Extracellular Vesicle Release from Staphylococcus aureus
The innate immune system uses Toll-like receptor (TLR) 2 to detect conserved bacterial lipoproteins of invading pathogens. The lipid anchor attaches lipoproteins to the cytoplasmic membrane and prevents their release from the bacterial cell envelope. How bacteria release lipoproteins and how these m...
Autores principales: | Schlatterer, Katja, Beck, Christian, Hanzelmann, Dennis, Lebtig, Marco, Fehrenbacher, Birgit, Schaller, Martin, Ebner, Patrick, Nega, Mulugeta, Otto, Michael, Kretschmer, Dorothee, Peschel, Andreas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247081/ https://www.ncbi.nlm.nih.gov/pubmed/30459192 http://dx.doi.org/10.1128/mBio.01851-18 |
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