Pharmaceutical Induction of PGC-1α Promotes Retinal Pigment Epithelial Cell Metabolism and Protects against Oxidative Damage

Retinal pigment epithelium (RPE) dysfunction due to accumulation of reactive oxygen species and oxidative damage is a key event in the development of age-related macular degeneration (AMD). Here, we examine the therapeutic potential of ZLN005, a selective PGC-1α transcriptional regulator, in protect...

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Detalles Bibliográficos
Autores principales: Satish, Sangeeta, Philipose, Hannah, Rosales, Mariana Aparecida Brunini, Saint-Geniez, Magali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247391/
https://www.ncbi.nlm.nih.gov/pubmed/30524663
http://dx.doi.org/10.1155/2018/9248640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247391/
https://www.ncbi.nlm.nih.gov/pubmed/30524663
http://dx.doi.org/10.1155/2018/9248640

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