TGF-β Regulates Cathepsin Activation during Normal and Pathogenic Development

Cysteine cathepsins play roles during development and disease beyond their function in lysosomal protein turnover. Here, we leverage a fluorescent activity-based probe (ABP), BMV109, to track cysteine cathepsins in normal and diseased zebrafish embryos. Using this probe in a model of mucolipidosis I...

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Detalles Bibliográficos
Autores principales: Flanagan-Steet, Heather, Christian, Courtney, Lu, Po-Nien, Aarnio-Peterson, Megan, Sanman, Laura, Archer-Hartmann, Stephanie, Azadi, Parastoo, Bogyo, Matthew, Steet, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247414/
https://www.ncbi.nlm.nih.gov/pubmed/29539424
http://dx.doi.org/10.1016/j.celrep.2018.02.066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247414/
https://www.ncbi.nlm.nih.gov/pubmed/29539424
http://dx.doi.org/10.1016/j.celrep.2018.02.066

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