Molecular characterization of sessile serrated adenoma/polyps with dysplasia/carcinoma based on immunohistochemistry, next-generation sequencing, and microsatellite instability testing: a case series study

BACKGROUND: Colorectal sessile serrated adenoma/polyps (SSA/Ps) are considered early precursor lesions in the serrated neoplasia pathway. Recent studies have shown associations of SSA/Ps with lost MLH1 expression, a CpG island methylator phenotype, and BRAF mutations. However, the molecular biologic...

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Detalles Bibliográficos
Autores principales: Murakami, Takashi, Akazawa, Yoichi, Yatagai, Noboru, Hiromoto, Takafumi, Sasahara, Noriko, Saito, Tsuyoshi, Sakamoto, Naoto, Nagahara, Akihito, Yao, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247685/
https://www.ncbi.nlm.nih.gov/pubmed/30458818
http://dx.doi.org/10.1186/s13000-018-0771-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247685/
https://www.ncbi.nlm.nih.gov/pubmed/30458818
http://dx.doi.org/10.1186/s13000-018-0771-3

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