Cargando…

Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H(2)O(2)-induced apoptosis in PC12 cells

PURPOSE: Reactive oxygen species (ROS) are considered a direct cause of neurodegenerative diseases (NDDs). Drugs developed to target ROS are effective for the treatment of NDDs. Orientin is a pyrone glucoside extracted from Polygonum orientale, and it exhibits many pharmacological activities. In thi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qi, Shimei, Feng, Zunyong, Li, Qiang, Qi, Zhilin, Zhang, Yao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248275/ https://www.ncbi.nlm.nih.gov/pubmed/30510405 http://dx.doi.org/10.2147/DDDT.S178217

Ejemplares similares

Myricitrin Modulates NADPH Oxidase-Dependent ROS Production to Inhibit Endotoxin-Mediated Inflammation by Blocking the JAK/STAT1 and NOX2/p47(phox) Pathways
por: Qi, Shimei, et al.
Publicado: (2017)

Orientin suppresses osteoclastogenesis and ameliorates ovariectomy‐induced osteoporosis via suppressing ROS production
por: Zheng, Yan, et al.
Publicado: (2023)

A Review on Medicinal Properties of Orientin
por: Lam, Kit Ying, et al.
Publicado: (2016)

Ocimum flavone Orientin as a countermeasure for thrombocytopenia
por: Yadav, Marshleen, et al.
Publicado: (2018)

Aloin Inhibits the Proliferation and Migration of Gastric Cancer Cells by Regulating NOX2–ROS-Mediated Pro-Survival Signal Pathways
por: Wang, Ziqian, et al.
Publicado: (2020)

Ginsenoside Rh1 Alleviates HK-2 Apoptosis by Inhibiting ROS and the JNK/p53 Pathways
por: Yang, Qi, et al.
Publicado: (2020)

Inhibition of ROS-Activated p38MAPK Pathway is Involved in the Protective Effect of H(2)S Against Chemical Hypoxia-Induced Inflammation in PC12 Cells
por: Lan, Aiping, et al.
Publicado: (2013)

Attenuation of Oxidative Stress of Erythrocytes by Plant-Derived Flavonoids, Orientin and Luteolin
por: An, Fang, et al.
Publicado: (2016)

Erythropoietin prevents PC12 cells from beta-amyloid-induced apoptosis via PI3K⁄Akt pathway
por: Zhi-Kun, Sun, et al.
Publicado: (2012)

Lysophosphatidylcholine enhances NGF-induced MAPK and Akt signals through the extracellular domain of TrkA in PC12 cells()
por: Wuhanqimuge, et al.
Publicado: (2013)

Salidroside inhibits the proliferation and migration of gastric cancer cells via suppression of Src-associated signaling pathway activation and heat shock protein 70 expression
por: Qi, Zhilin, et al.
Publicado: (2018)

Protective Effect of Tetrahydroxystilbene Glucoside on 6-OHDA-Induced Apoptosis in PC12 Cells through the ROS-NO Pathway
por: Tao, Lizhen, et al.
Publicado: (2011)

Osthole Attenuates Doxorubicin-Induced Apoptosis in PC12 Cells through Inhibition of Mitochondrial Dysfunction and ROS Production
por: Shokoohinia, Yalda, et al.
Publicado: (2014)

Erigeron annuus Protects PC12 Neuronal Cells from Oxidative Stress Induced by ROS-Mediated Apoptosis
por: Lee, Ji Yeon, et al.
Publicado: (2020)

DHA ameliorates MeHg-induced PC12 cell apoptosis by inhibiting the ROS/JNK signaling pathway
por: Zhang, Hong, et al.
Publicado: (2021)

Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway
por: Zhang, Jie, et al.
Publicado: (2020)

RETRACTED ARTICLE: Chinese medicine Di-Huang-Yi-Zhi protects PC12 cells from H(2)O(2)-induced apoptosis by regulating ROS-ASK1-JNK/p38 MAPK signaling
por: Zhang, Li-Min, et al.
Publicado: (2020)

Retraction Note: Chinese medicine Di-Huang-Yi-Zhi protects PC12 cells from H(2)O(2)-induced apoptosis by regulating ROS-ASK1-JNK/p38 MAPK signaling
por: Zhang, Li-Min, et al.
Publicado: (2022)

Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway
por: Cao, Wen-qiang, et al.
Publicado: (2019)

MiR-103 alleviates autophagy and apoptosis by regulating SOX2 in LPS-injured PC12 cells and SCI rats
por: Li, Guowei, et al.
Publicado: (2018)

Plantamajoside alleviates hypoxia-reoxygenation injury through integrin-linked kinase/c-Src/Akt and the mitochondrial apoptosis signaling pathways in H9c2 myocardial cells
por: Du, Yuying, et al.
Publicado: (2023)

Zeaxanthin Induces Apoptosis via ROS-Regulated MAPK and AKT Signaling Pathway in Human Gastric Cancer Cells
por: Sheng, Ya-Nan, et al.
Publicado: (2020)

Orientin mediates protection against MRSA-induced pneumonia by inhibiting Sortase A
por: Wang, Li, et al.
Publicado: (2021)

Orientin Enhances Colistin-Mediated Bacterial Lethality through Oxidative Stress Involvement
por: Khumbulani, Madonsela, et al.
Publicado: (2022)

Ginsenoside Rb1 Prevents MPP(+)-Induced Apoptosis in PC12 Cells by Stimulating Estrogen Receptors with Consequent Activation of ERK1/2, Akt and Inhibition of SAPK/JNK, p38 MAPK
por: Hashimoto, Ryo, et al.
Publicado: (2012)

SGT1 is required in PcINF1/SRC2-1 induced pepper defense response by interacting with SRC2-1
por: Liu, Zhi-qin, et al.
Publicado: (2016)

Protective Effects of Lycium barbarum Polysaccharide on 6-OHDA-Induced Apoptosis in PC12 Cells through the ROS-NO Pathway
por: Gao, Kai, et al.
Publicado: (2014)

STIM1 controls calcineurin/Akt/mTOR/NFATC2-mediated osteoclastogenesis induced by RANKL/M-CSF
por: Huang, Yanjiao, et al.
Publicado: (2020)

Hydrogen Sulfide Protects against Chemical Hypoxia-Induced Injury by Inhibiting ROS-Activated ERK1/2 and p38MAPK Signaling Pathways in PC12 Cells
por: Lan, Aiping, et al.
Publicado: (2011)

Salidroside protects PC-12 cells against amyloid β-induced apoptosis by activation of the ERK1/2 and AKT signaling pathways
por: Liao, Zheng-Luan, et al.
Publicado: (2019)

Ly6G+ neutrophil-derived miR-223 inhibits the NLRP3 inflammasome in mitochondrial DAMP-induced acute lung injury
por: Feng, Zunyong, et al.
Publicado: (2017)

LAMTOR2-Mediated Modulation of NGF/MAPK Activation Kinetics during Differentiation of PC12 Cells
por: Thauerer, Bettina, et al.
Publicado: (2014)

Ginsenoside-Rd Promotes Neurite Outgrowth of PC12 Cells through MAPK/ERK- and PI3K/AKT-Dependent Pathways
por: Wu, Song-Di, et al.
Publicado: (2016)

Klotho Alleviates Lung Injury Caused by Paraquat via Suppressing ROS/P38 MAPK-Regulated Inflammatory Responses and Apoptosis
por: Zhang, Zhiqiang, et al.
Publicado: (2020)

Antioxidant effects of the orientin and vitexin in Trollius chinensis Bunge in D-galactose-aged mice★
por: An, Fang, et al.
Publicado: (2012)

Tyrosine-specific MAPK phosphatases and the control of ERK signaling in PC12 cells
por: Noordman, Yvet E, et al.
Publicado: (2006)

Protection of Tong-Sai-Mai Decoction against Apoptosis Induced by H(2)O(2) in PC12 Cells: Mechanisms via Bcl-2-Mitochondria-ROS-INOS Pathway
por: Lee, Maxwell Kim Kit, et al.
Publicado: (2014)

Upregulation of Glutaminyl Cyclase Contributes to ERS-Induced Apoptosis in PC12 Cells
por: Shang, Qi, et al.
Publicado: (2022)

Ferulic acid protects PC12 neurons against hypoxia by inhibiting the p-MAPKs and COX-2 pathways
por: Lin, Wen-Chieh, et al.
Publicado: (2015)

Fusobacterium nucleatum Facilitates Apoptosis, ROS Generation, and Inflammatory Cytokine Production by Activating AKT/MAPK and NF-κB Signaling Pathways in Human Gingival Fibroblasts
por: Kang, Wenyan, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_kuf9lcg7dqafarv1olr15mnqcu