Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation

We apply integrative approaches to expression quantitative loci (eQTLs) from 44 tissues from the GTEx Project and genome-wide association study (GWAS) data. About 60% of known trait-associated loci are in linkage disequilibrium with a cis-eQTL, over half of which were not found in previous large-sca...

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Detalles Bibliográficos
Autores principales: Gamazon, Eric R., Segrè, Ayellet V., van de Bunt, Martijn, Wen, Xiaoquan, Xi, Hualin S., Hormozdiari, Farhad, Ongen, Halit, Konkashbaev, Anuar, Derks, Eske M., Aguet, François, Quan, Jie, Nicolae, Dan L., Eskin, Eleazar, Kellis, Manolis, Getz, Gad, McCarthy, Mark I., Dermitzakis, Emmanouil T., Cox, Nancy J., Ardlie, Kristin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248311/
https://www.ncbi.nlm.nih.gov/pubmed/29955180
http://dx.doi.org/10.1038/s41588-018-0154-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248311/
https://www.ncbi.nlm.nih.gov/pubmed/29955180
http://dx.doi.org/10.1038/s41588-018-0154-4

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