Cargando…
Analysis of 7,815 cancer exomes reveals associations between mutational processes and somatic driver mutations
Driver mutations are the genetic variants responsible for oncogenesis, but how specific somatic mutational events arise in cells remains poorly understood. Mutational signatures derive from the frequency of mutated trinucleotides in a given cancer sample, and they provide an avenue for investigating...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249022/ https://www.ncbi.nlm.nih.gov/pubmed/30412573 http://dx.doi.org/10.1371/journal.pgen.1007779 |