IL-21 and anti-CD40 restore Bcl-2 family protein imbalance in vitro in low-survival CD27(+) B cells from CVID patients

Common variable immunodeficiency (CVID) is characterized by an abnormal B cell differentiation to memory and antibody-secreting B cells. The defective functionality of CVID patients’ B cells could be the consequence of alterations in apoptosis regulation. We studied the balance of Bcl-2 family anti-...

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Detalles Bibliográficos
Autores principales: López-Gómez, Antonio, Clemente, Antonio, Cunill, Vanesa, Pons, Jaime, Ferrer, Joana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249202/
https://www.ncbi.nlm.nih.gov/pubmed/30464201
http://dx.doi.org/10.1038/s41419-018-1191-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249202/
https://www.ncbi.nlm.nih.gov/pubmed/30464201
http://dx.doi.org/10.1038/s41419-018-1191-8

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