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Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B(12)

The only known source of vitamin B(12) (adenosylcobalamin) is from bacteria and archaea. Here, using genetic and metabolic engineering, we generate an Escherichia coli strain that produces vitamin B(12) via an engineered de novo aerobic biosynthetic pathway. In vitro and/or in vivo analysis of genes...

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Detalles Bibliográficos
Autores principales: Fang, Huan, Li, Dong, Kang, Jie, Jiang, Pingtao, Sun, Jibin, Zhang, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249242/
https://www.ncbi.nlm.nih.gov/pubmed/30464241
http://dx.doi.org/10.1038/s41467-018-07412-6