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Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B(12)
The only known source of vitamin B(12) (adenosylcobalamin) is from bacteria and archaea. Here, using genetic and metabolic engineering, we generate an Escherichia coli strain that produces vitamin B(12) via an engineered de novo aerobic biosynthetic pathway. In vitro and/or in vivo analysis of genes...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249242/ https://www.ncbi.nlm.nih.gov/pubmed/30464241 http://dx.doi.org/10.1038/s41467-018-07412-6 |