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COMP and TSP-4 interact specifically with the novel GXKGHR motif only found in fibrillar collagens

COMP (cartilage oligomeric matrix protein) is a member of the thrombospondin family and forms homopentamers as well as mixed heterooligomers with its closely related family member TSP-4. COMP is long known to bind to collagens and to influence collagen fibril formation. Recent work indicates that al...

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Detalles Bibliográficos
Autores principales: Gebauer, Jan M., Köhler, Anna, Dietmar, Helen, Gompert, Monika, Neundorf, Ines, Zaucke, Frank, Koch, Manuel, Baumann, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249252/
https://www.ncbi.nlm.nih.gov/pubmed/30464261
http://dx.doi.org/10.1038/s41598-018-35447-8