A split luciferase-based probe for quantitative proximal determination of Gα(q) signalling in live cells

The earlier an activation of a G protein-dependent signalling cascade at a G protein-coupled receptor (GPCR) is probed, the less amplificatory effects contribute to the measured signal. This is especially useful in case of a precise quantification of agonist efficacies, and is of paramount importanc...

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Detalles Bibliográficos
Autores principales: Littmann, Timo, Ozawa, Takeaki, Hoffmann, Carsten, Buschauer, Armin, Bernhardt, Günther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249299/
https://www.ncbi.nlm.nih.gov/pubmed/30464299
http://dx.doi.org/10.1038/s41598-018-35615-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249299/
https://www.ncbi.nlm.nih.gov/pubmed/30464299
http://dx.doi.org/10.1038/s41598-018-35615-w

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