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A split luciferase-based probe for quantitative proximal determination of Gα(q) signalling in live cells
The earlier an activation of a G protein-dependent signalling cascade at a G protein-coupled receptor (GPCR) is probed, the less amplificatory effects contribute to the measured signal. This is especially useful in case of a precise quantification of agonist efficacies, and is of paramount importanc...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249299/ https://www.ncbi.nlm.nih.gov/pubmed/30464299 http://dx.doi.org/10.1038/s41598-018-35615-w |