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FAST-1 antisense RNA epigenetically alters FXN expression

Friedreich ataxia (FRDA) is a multisystem genetic disorder caused by GAA repeat expansion mutations within the FXN gene, resulting in heterochromatin formation and deficiency of frataxin protein. Elevated levels of the FXN antisense transcript (FAST-1) have previously been detected in FRDA. To inves...

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Detalles Bibliográficos
Autores principales: Mikaeili, Hajar, Sandi, Madhavi, Bayot, Aurélien, Al-Mahdawi, Sahar, Pook, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249312/
https://www.ncbi.nlm.nih.gov/pubmed/30464193
http://dx.doi.org/10.1038/s41598-018-35639-2