Cargando…

FAST-1 antisense RNA epigenetically alters FXN expression

Friedreich ataxia (FRDA) is a multisystem genetic disorder caused by GAA repeat expansion mutations within the FXN gene, resulting in heterochromatin formation and deficiency of frataxin protein. Elevated levels of the FXN antisense transcript (FAST-1) have previously been detected in FRDA. To inves...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mikaeili, Hajar, Sandi, Madhavi, Bayot, Aurélien, Al-Mahdawi, Sahar, Pook, Mark A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249312/ https://www.ncbi.nlm.nih.gov/pubmed/30464193 http://dx.doi.org/10.1038/s41598-018-35639-2

Ejemplares similares

Friedreich Ataxia Patient Tissues Exhibit Increased 5-Hydroxymethylcytosine Modification and Decreased CTCF Binding at the FXN Locus
por: Al-Mahdawi, Sahar, et al.
Publicado: (2013)

Epigenetic-based therapies for Friedreich ataxia
por: Sandi, Chiranjeevi, et al.
Publicado: (2014)

Epigenetics in Friedreich's Ataxia: Challenges and Opportunities for Therapy
por: Sandi, Chiranjeevi, et al.
Publicado: (2013)

A new FRDA mouse model [Fxn(null):YG8s(GAA) > 800] with more than 800 GAA repeats
por: Kalef-Ezra, Ester, et al.
Publicado: (2023)

MutLα Heterodimers Modify the Molecular Phenotype of Friedreich Ataxia
por: Ezzatizadeh, Vahid, et al.
Publicado: (2014)

Pharmacological Screening Using an FXN-EGFP Cellular Genomic Reporter Assay for the Therapy of Friedreich Ataxia
por: Li, Lingli, et al.
Publicado: (2013)

Generation and Characterisation of Friedreich Ataxia YG8R Mouse Fibroblast and Neural Stem Cell Models
por: Sandi, Chiranjeevi, et al.
Publicado: (2014)

A novel GAA-repeat-expansion-based mouse model of Friedreich’s ataxia
por: Anjomani Virmouni, Sara, et al.
Publicado: (2015)

Analysis of Putative Epigenetic Regulatory Elements in the FXN Genomic Locus
por: Fernández-Frías, Iván, et al.
Publicado: (2020)

Epigenetic Heterogeneity in Friedreich Ataxia Underlies Variable FXN Reactivation
por: Rodden, Layne N., et al.
Publicado: (2021)

Large Interruptions of GAA Repeat Expansion Mutations in Friedreich Ataxia Are Very Rare
por: Al-Mahdawi, Sahar, et al.
Publicado: (2018)

FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia
por: Chutake, Yogesh K., et al.
Publicado: (2015)

Cellular, Molecular and Functional Characterisation of YAC Transgenic Mouse Models of Friedreich Ataxia
por: Anjomani Virmouni, Sara, et al.
Publicado: (2014)

G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects
por: Wang, Feng, et al.
Publicado: (2022)

Long Range Regulation of Human FXN Gene Expression
por: Puspasari, Novita, et al.
Publicado: (2011)

Effect of Mitochondrial and Cytosolic FXN Isoform Expression on Mitochondrial Dynamics and Metabolism
por: Agrò, Mauro, et al.
Publicado: (2020)

HMTase Inhibitors as a Potential Epigenetic-Based Therapeutic Approach for Friedreich’s Ataxia
por: Sherzai, Mursal, et al.
Publicado: (2020)

Identification of telomere dysfunction in Friedreich ataxia
por: Anjomani Virmouni, Sara, et al.
Publicado: (2015)

Interruptions of the FXN GAA Repeat Tract Delay the Age at Onset of Friedreich’s Ataxia in a Location Dependent Manner
por: Nethisinghe, Suran, et al.
Publicado: (2021)

FXN gene methylation determines carrier status in Friedreich ataxia
por: Lam, Christina, et al.
Publicado: (2023)

The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases
por: Al-Mahdawi, Sahar, et al.
Publicado: (2014)

Genetic Variations Creating MicroRNA Target Sites in the FXN 3′-UTR Affect Frataxin Expression in Friedreich Ataxia
por: Bandiera, Simonetta, et al.
Publicado: (2013)

Analyzing the Effects of a G137V Mutation in the FXN Gene
por: Faggianelli, Nathalie, et al.
Publicado: (2015)

Pms2 Suppresses Large Expansions of the (GAA·TTC)(n) Sequence in Neuronal Tissues
por: Bourn, Rebecka L., et al.
Publicado: (2012)

Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich’s ataxia
por: Kim, Eunah, et al.
Publicado: (2011)

Identification of a novel missense mutation in Friedreich's ataxia –FXN(W) (168R)
por: Clark, Elisia, et al.
Publicado: (2019)

Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model
por: Tomassini, Barbara, et al.
Publicado: (2012)

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model
por: Sandi, Chiranjeevi, et al.
Publicado: (2011)

Rescue of the Friedreich Ataxia Knockout Mutation in Transgenic Mice Containing an FXN-EGFP Genomic Reporter
por: Sarsero, Joseph P., et al.
Publicado: (2014)

Frataxin‐deficient neurons and mice models of Friedreich ataxia are improved by TAT‐MTScs‐FXN treatment
por: Britti, Elena, et al.
Publicado: (2017)

Iron-induced oligomerization of human FXN(81-210) and bacterial CyaY frataxin and the effect of iron chelators
por: Ahlgren, Eva-Christina, et al.
Publicado: (2017)

A Comprehensive Transcriptome Analysis Identifies FXN and BDNF as Novel Targets of miRNAs in Friedreich’s Ataxia Patients
por: Misiorek, Julia O., et al.
Publicado: (2020)

Mice harboring the FXN I151F pathological point mutation present decreased frataxin levels, a Friedreich ataxia-like phenotype, and mitochondrial alterations
por: Medina-Carbonero, Marta, et al.
Publicado: (2022)

Ustilago maydis natural antisense transcript expression alters mRNA stability and pathogenesis
por: Donaldson, Michael E, et al.
Publicado: (2013)

An antisense intragenic lncRNA SEAIRa mediates transcriptional and epigenetic repression of SERRATE in Arabidopsis
por: Chen, Wei, et al.
Publicado: (2023)

Friedreich's Ataxia, Frataxin, PIP5K1B: Echo of a Distant Fracas
por: Bayot, Aurélien, et al.
Publicado: (2013)

Expression of antisense RNA fails to inhibit influenza virus replication
por: Leiter, Josef M.E., et al.
Publicado: (1989)

Epigenetic regulation of human cis-natural antisense transcripts
por: Conley, Andrew B., et al.
Publicado: (2012)

Hypoxia-Sensitive Epigenetic Regulation of an Antisense-Oriented lncRNA Controls WT1 Expression in Myeloid Leukemia Cells
por: McCarty, Gregory, et al.
Publicado: (2015)

A Drug Combination Rescues Frataxin-Dependent Neural and Cardiac Pathophysiology in FA Models
por: Abeti, Rosella, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_n61up331u65ogt43ce7t5retj0