A patient-derived cellular model for Huntington’s disease reveals phenotypes at clinically relevant CAG lengths

The huntingtin protein participates in several cellular processes that are disrupted when the polyglutamine tract is expanded beyond a threshold of 37 CAG DNA repeats in Huntington’s disease (HD). Cellular biology approaches to understand these functional disruptions in HD have primarily focused on...

Descripción completa

Detalles Bibliográficos
Autores principales: Hung, Claudia Lin-Kar, Maiuri, Tamara, Bowie, Laura Erin, Gotesman, Ryan, Son, Susie, Falcone, Mina, Giordano, James Victor, Gillis, Tammy, Mattis, Virginia, Lau, Trevor, Kwan, Vickie, Wheeler, Vanessa, Schertzer, Jonathan, Singh, Karun, Truant, Ray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249865/
https://www.ncbi.nlm.nih.gov/pubmed/30256717
http://dx.doi.org/10.1091/mbc.E18-09-0590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249865/
https://www.ncbi.nlm.nih.gov/pubmed/30256717
http://dx.doi.org/10.1091/mbc.E18-09-0590

Ejemplares similares