Asterless is a Polo-like kinase 4 substrate that both activates and inhibits kinase activity depending on its phosphorylation state

Centriole assembly initiates when Polo-like kinase 4 (Plk4) interacts with a centriole “targeting-factor.” In Drosophila, Asterless/Asl (Cep152 in humans) fulfills the targeting role. Interestingly, Asl also regulates Plk4 levels. The N-terminus of Asl (Asl-A; amino acids 1-374) binds Plk4 and promo...

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Detalles Bibliográficos
Autores principales: Boese, Cody J., Nye, Jonathan, Buster, Daniel W., McLamarrah, Tiffany A., Byrnes, Amy E., Slep, Kevin C., Rusan, Nasser M., Rogers, Gregory C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249866/
https://www.ncbi.nlm.nih.gov/pubmed/30256714
http://dx.doi.org/10.1091/mbc.E18-07-0445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249866/
https://www.ncbi.nlm.nih.gov/pubmed/30256714
http://dx.doi.org/10.1091/mbc.E18-07-0445

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