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Antioxidant properties of topical Caulerpa sp. extract on UVB-induced photoaging in mice

Caulerpa sp., a genus of seaweed native to the Indo-Pacific region, has been known for its antioxidant properties and health benefits when consumed as food. Previous studies have reported Caulerpa sp.’s potential as a strong antioxidant, but its effects on the skin in a topical preparation, especial...

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Autores principales: Wiraguna, Anak Agung Gde Putra, Pangkahila, Wimpie, Astawa, I. Nyoman Mantik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250079/
https://www.ncbi.nlm.nih.gov/pubmed/30555666
http://dx.doi.org/10.4081/dr.2018.7597
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author Wiraguna, Anak Agung Gde Putra
Pangkahila, Wimpie
Astawa, I. Nyoman Mantik
author_facet Wiraguna, Anak Agung Gde Putra
Pangkahila, Wimpie
Astawa, I. Nyoman Mantik
author_sort Wiraguna, Anak Agung Gde Putra
collection PubMed
description Caulerpa sp., a genus of seaweed native to the Indo-Pacific region, has been known for its antioxidant properties and health benefits when consumed as food. Previous studies have reported Caulerpa sp.’s potential as a strong antioxidant, but its effects on the skin in a topical preparation, especially its role in ultraviolet (UV) protection, have not been studied extensively. Our study investigated the protective effects of 0.2% and 0.4% Caulerpa sp. extract gels on photoaging in the UVB-irradiated skin of Wistar mice. The subjects were divided into naive control, vehicle control, and 3 treatment groups (0.2% Caulerpa sp. extract gel, 0.4% Caulerpa sp. extract gel, and 0.02% astaxanthin gel as a standard antioxidant). The groups, except the naive control group, received a total of 840 mJ/cm(2) of UVB irradiation in four weeks. Protective effects of the extract were measured through the evaluation of collagen expression, matrix metalloproteinase (MMP)-1 expression and levels, and 8-OhDG expression. Mice who received topical application of Caulerpa sp. extract gel had higher collagen expression, better-preserved collagen structure, lower levels of MMP-1, and less MMP-1 and 8-OHdG expressions compared to the vehicle control group. There was no difference between different concentrations of the extract. Our findings demonstrated that topical application of Caulerpa sp. extract gel significantly protected UVB-irradiated mice skin from photoaging.
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spelling pubmed-62500792018-12-14 Antioxidant properties of topical Caulerpa sp. extract on UVB-induced photoaging in mice Wiraguna, Anak Agung Gde Putra Pangkahila, Wimpie Astawa, I. Nyoman Mantik Dermatol Reports Article Caulerpa sp., a genus of seaweed native to the Indo-Pacific region, has been known for its antioxidant properties and health benefits when consumed as food. Previous studies have reported Caulerpa sp.’s potential as a strong antioxidant, but its effects on the skin in a topical preparation, especially its role in ultraviolet (UV) protection, have not been studied extensively. Our study investigated the protective effects of 0.2% and 0.4% Caulerpa sp. extract gels on photoaging in the UVB-irradiated skin of Wistar mice. The subjects were divided into naive control, vehicle control, and 3 treatment groups (0.2% Caulerpa sp. extract gel, 0.4% Caulerpa sp. extract gel, and 0.02% astaxanthin gel as a standard antioxidant). The groups, except the naive control group, received a total of 840 mJ/cm(2) of UVB irradiation in four weeks. Protective effects of the extract were measured through the evaluation of collagen expression, matrix metalloproteinase (MMP)-1 expression and levels, and 8-OhDG expression. Mice who received topical application of Caulerpa sp. extract gel had higher collagen expression, better-preserved collagen structure, lower levels of MMP-1, and less MMP-1 and 8-OHdG expressions compared to the vehicle control group. There was no difference between different concentrations of the extract. Our findings demonstrated that topical application of Caulerpa sp. extract gel significantly protected UVB-irradiated mice skin from photoaging. PAGEPress Publications, Pavia, Italy 2018-10-01 /pmc/articles/PMC6250079/ /pubmed/30555666 http://dx.doi.org/10.4081/dr.2018.7597 Text en ©Copyright A.A.G.P. Wiraguna et al., 2018 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Wiraguna, Anak Agung Gde Putra
Pangkahila, Wimpie
Astawa, I. Nyoman Mantik
Antioxidant properties of topical Caulerpa sp. extract on UVB-induced photoaging in mice
title Antioxidant properties of topical Caulerpa sp. extract on UVB-induced photoaging in mice
title_full Antioxidant properties of topical Caulerpa sp. extract on UVB-induced photoaging in mice
title_fullStr Antioxidant properties of topical Caulerpa sp. extract on UVB-induced photoaging in mice
title_full_unstemmed Antioxidant properties of topical Caulerpa sp. extract on UVB-induced photoaging in mice
title_short Antioxidant properties of topical Caulerpa sp. extract on UVB-induced photoaging in mice
title_sort antioxidant properties of topical caulerpa sp. extract on uvb-induced photoaging in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250079/
https://www.ncbi.nlm.nih.gov/pubmed/30555666
http://dx.doi.org/10.4081/dr.2018.7597
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