Engineering the hinge region of human IgG1 Fc-fused bispecific antibodies to improve fragmentation resistance

Fc domain fusion can improve the therapeutic effects of relatively small biological molecules such as peptides, cytokines, and antibody fragments. Fc fusion proteins can also be used to enhance the cytotoxic effects of small bispecific antibodies (bsAbs). However, fragmentation of Fc fusion proteins...

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Detalles Bibliográficos
Autores principales: Suzuki, Saori, Annaka, Hiroaki, Konno, Shota, Kumagai, Izumi, Asano, Ryutaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250740/
https://www.ncbi.nlm.nih.gov/pubmed/30467410
http://dx.doi.org/10.1038/s41598-018-35489-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250740/
https://www.ncbi.nlm.nih.gov/pubmed/30467410
http://dx.doi.org/10.1038/s41598-018-35489-y

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