Neuroprotection by Heat Shock Factor-1 (HSF1) and Trimerization-Deficient Mutant Identifies Novel Alterations in Gene Expression

Heat shock factor-1 (HSF1) protects neurons from death caused by the accumulation of misfolded proteins by stimulating the transcription of genes encoding heat shock proteins (HSPs). This stimulatory action depends on the association of trimeric HSF1 to sequences within HSP gene promoters. However,...

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Detalles Bibliográficos
Autores principales: Qu, Zhe, Titus, Anto Sam Crosslee Louis Sam, Xuan, Zhenyu, D’Mello, Santosh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250741/
https://www.ncbi.nlm.nih.gov/pubmed/30467350
http://dx.doi.org/10.1038/s41598-018-35610-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250741/
https://www.ncbi.nlm.nih.gov/pubmed/30467350
http://dx.doi.org/10.1038/s41598-018-35610-1

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