The HDAC6 inhibitor C1A modulates autophagy substrates in diverse cancer cells and induces cell death

BACKGROUND: Cytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the autophagy degradation pathway of malformed proteins, an important survival mechanism in cancer cells. We evaluated modulation of autophagy-related proteins and cell death by the HDAC6-selective inhibitor C1A. METHODS:...

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Detalles Bibliográficos
Autores principales: Kaliszczak, Maciej, van Hechanova, Erich, Li, Yunqing, Alsadah, Hibah, Parzych, Katarzyna, Auner, Holger W., Aboagye, Eric O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251030/
https://www.ncbi.nlm.nih.gov/pubmed/30318510
http://dx.doi.org/10.1038/s41416-018-0232-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251030/
https://www.ncbi.nlm.nih.gov/pubmed/30318510
http://dx.doi.org/10.1038/s41416-018-0232-5

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