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The HDAC6 inhibitor C1A modulates autophagy substrates in diverse cancer cells and induces cell death

BACKGROUND: Cytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the autophagy degradation pathway of malformed proteins, an important survival mechanism in cancer cells. We evaluated modulation of autophagy-related proteins and cell death by the HDAC6-selective inhibitor C1A. METHODS:...

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Detalles Bibliográficos
Autores principales:	Kaliszczak, Maciej, van Hechanova, Erich, Li, Yunqing, Alsadah, Hibah, Parzych, Katarzyna, Auner, Holger W., Aboagye, Eric O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251030/ https://www.ncbi.nlm.nih.gov/pubmed/30318510 http://dx.doi.org/10.1038/s41416-018-0232-5

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