GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions

BACKGROUND: Although diabetic retinopathy (DR) has long been considered as a microvascular disorder, mounting evidence suggests that diabetic retinal neurodegeneration, in particular synaptic loss and dysfunction of retinal ganglion cells (RGCs) may precede retinal microvascular changes. Key molecul...

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Detalles Bibliográficos
Autores principales: Zhu, Huazhang, Zhang, Weizhen, Zhao, Yingying, Shu, Xingsheng, Wang, Wencong, Wang, Dandan, Yang, Yangfan, He, Zhijun, Wang, Xiaomei, Ying, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251088/
https://www.ncbi.nlm.nih.gov/pubmed/30466464
http://dx.doi.org/10.1186/s13024-018-0295-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251088/
https://www.ncbi.nlm.nih.gov/pubmed/30466464
http://dx.doi.org/10.1186/s13024-018-0295-z

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