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Induction of chronic destructive arthritis in SCID mice by arthritogenic fibroblast-like synoviocytes derived from mice with antigen-induced arthritis

BACKGROUND: Fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA) are autonomously activated to maintain inflammation and joint destruction in co-transplantation models. To elucidate inducing mechanisms involved in this altered behavior, the arthritogenic potential of FLSs...

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Detalles Bibliográficos
Autores principales: Frey, Oliver, Hückel, Marion, Gajda, Mieczyslaw, Petrow, Peter K., Bräuer, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251107/
https://www.ncbi.nlm.nih.gov/pubmed/30466479
http://dx.doi.org/10.1186/s13075-018-1720-y