Observation weights unlock bulk RNA-seq tools for zero inflation and single-cell applications

Dropout events in single-cell RNA sequencing (scRNA-seq) cause many transcripts to go undetected and induce an excess of zero read counts, leading to power issues in differential expression (DE) analysis. This has triggered the development of bespoke scRNA-seq DE methods to cope with zero inflation....

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Detalles Bibliográficos
Autores principales: Van den Berge, Koen, Perraudeau, Fanny, Soneson, Charlotte, Love, Michael I., Risso, Davide, Vert, Jean-Philippe, Robinson, Mark D., Dudoit, Sandrine, Clement, Lieven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251479/
https://www.ncbi.nlm.nih.gov/pubmed/29478411
http://dx.doi.org/10.1186/s13059-018-1406-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251479/
https://www.ncbi.nlm.nih.gov/pubmed/29478411
http://dx.doi.org/10.1186/s13059-018-1406-4

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