T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1

Leukemia stem cells (LSCs) are regarded as the origins and key therapeutic targets of leukemia, but limited knowledge is available on the key determinants of LSC ‘stemness’. Using single-cell RNA-seq analysis, we identify a master regulator, SPI1, the LSC-specific expression of which determines the...

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Detalles Bibliográficos
Autores principales: Zhu, Haichuan, Zhang, Liuzhen, Wu, Yilin, Dong, Bingjie, Guo, Weilong, Wang, Mei, Yang, Lu, Fan, Xiaoying, Tang, Yuliang, Liu, Ningshu, Lei, Xiaoguang, Wu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251627/
https://www.ncbi.nlm.nih.gov/pubmed/30412053
http://dx.doi.org/10.7554/eLife.38314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251627/
https://www.ncbi.nlm.nih.gov/pubmed/30412053
http://dx.doi.org/10.7554/eLife.38314

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