Novel benzamido derivatives as PTP1B inhibitors with anti-hyperglycemic and lipid-lowering efficacy

Based on a non-competitive and selective PTP1B inhibitor reported by us previously, thirty-nine benzamido derivatives were designed and synthesized as novel PTP1B inhibitors. Among them, twelve compounds exhibited IC(50) values at micromolar level against human recombinant PTP1B, and most of them ex...

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Detalles Bibliográficos
Autores principales: Tang, Yanbo, Zhang, Xiaolin, Chen, Zheng, Yin, Wenwen, Nan, Guanglei, Tian, Jinying, Ye, Fei, Xiao, Zhiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251817/
https://www.ncbi.nlm.nih.gov/pubmed/30505661
http://dx.doi.org/10.1016/j.apsb.2018.05.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251817/
https://www.ncbi.nlm.nih.gov/pubmed/30505661
http://dx.doi.org/10.1016/j.apsb.2018.05.001

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