Cobalt-catalyzed difluoroalkylation of tertiary aryl ketones for facile synthesis of quaternary alkyl difluorides

The selective incorporation of gem-difluoroalkyl groups into biologically active molecules has long been used as an efficient strategy for drug design and discovery. However, the catalytic C(sp(3))-CF(2) bond-forming cross-coupling reaction for selective incorporation of difluoromethylene group into...

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Detalles Bibliográficos
Autores principales: Li, Chao, Cao, Yi-Xuan, Wang, Rui, Wang, Yi-Ning, Lan, Quan, Wang, Xi-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251884/
https://www.ncbi.nlm.nih.gov/pubmed/30470757
http://dx.doi.org/10.1038/s41467-018-07525-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251884/
https://www.ncbi.nlm.nih.gov/pubmed/30470757
http://dx.doi.org/10.1038/s41467-018-07525-y

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