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Cobalt-catalyzed difluoroalkylation of tertiary aryl ketones for facile synthesis of quaternary alkyl difluorides
The selective incorporation of gem-difluoroalkyl groups into biologically active molecules has long been used as an efficient strategy for drug design and discovery. However, the catalytic C(sp(3))-CF(2) bond-forming cross-coupling reaction for selective incorporation of difluoromethylene group into...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251884/ https://www.ncbi.nlm.nih.gov/pubmed/30470757 http://dx.doi.org/10.1038/s41467-018-07525-y |