CKD-506, a novel HDAC6-selective inhibitor, improves renal outcomes and survival in a mouse model of systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a chronic multisystemic autoimmune disease with an unknown etiology. Recently, it has been elucidated that dysregulated histone deacetylase (HDAC) activity is related to the pathogenesis of inflammatory and autoimmune diseases. Broad-spectrum HDAC inhibitors are...

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Detalles Bibliográficos
Autores principales: Choi, Eun Wha, Song, Ji Woo, Ha, Nina, Choi, Young Il, Kim, Sungjoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251916/
https://www.ncbi.nlm.nih.gov/pubmed/30470828
http://dx.doi.org/10.1038/s41598-018-35602-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251916/
https://www.ncbi.nlm.nih.gov/pubmed/30470828
http://dx.doi.org/10.1038/s41598-018-35602-1

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