Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance

Genomic intratumoral heterogeneity (ITH) is common in cancers, but the extent of phenotypic ITH is uncertain because most subclonal mutations are passengers. Since tumor phenotypes are largely driven by epigenetics, methylomic analyses can provide insights into phenotypic ITH. Following this princip...

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Detalles Bibliográficos
Autores principales: Ryser, Marc D., Yu, Ming, Grady, William, Siegmund, Kimberly, Shibata, Darryl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251922/
https://www.ncbi.nlm.nih.gov/pubmed/30470817
http://dx.doi.org/10.1038/s41598-018-35621-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251922/
https://www.ncbi.nlm.nih.gov/pubmed/30470817
http://dx.doi.org/10.1038/s41598-018-35621-y

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