CXCL12 blockade preferentially regenerates lost podocytes in cortical nephrons by targeting an intrinsic podocyte-progenitor feedback mechanism

Insufficient podocyte regeneration after injury is a central pathomechanism of glomerulosclerosis and chronic kidney disease. Podocytes constitutively secrete the chemokine CXCL12, which is known to regulate homing and activation of stem cells; hence we hypothesized a similar effect of CXCL12 on pod...

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Detalles Bibliográficos
Autores principales: Romoli, Simone, Angelotti, Maria Lucia, Antonelli, Giulia, Kumar VR, Santhosh, Mulay, Shrikant R., Desai, Jyaysi, Anguiano Gomez, Lidia, Thomasova, Dana, Eulberg, Dirk, Klussmann, Sven, Melica, Maria Elena, Conte, Carolina, Lombardi, Duccio, Lasagni, Laura, Anders, Hans-Joachim, Romagnani, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251974/
https://www.ncbi.nlm.nih.gov/pubmed/30385042
http://dx.doi.org/10.1016/j.kint.2018.08.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251974/
https://www.ncbi.nlm.nih.gov/pubmed/30385042
http://dx.doi.org/10.1016/j.kint.2018.08.013

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