Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis

The contribution of epithelial–mesenchymal transition (EMT) to human lung fibrogenesis is controversial. Here we provide evidence that ZEB1-mediated EMT in human alveolar epithelial type II (ATII) cells contributes to the development of lung fibrosis by paracrine signalling to underlying fibroblasts...

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Detalles Bibliográficos
Autores principales: Yao, Liudi, Conforti, Franco, Hill, Charlotte, Bell, Joseph, Drawater, Leena, Li, Juanjuan, Liu, Dian, Xiong, Hua, Alzetani, Aiman, Chee, Serena J., Marshall, Ben G., Fletcher, Sophie V., Hancock, David, Coldwell, Mark, Yuan, Xianglin, Ottensmeier, Christian H., Downward, Julian, Collins, Jane E., Ewing, Rob M., Richeldi, Luca, Skipp, Paul, Jones, Mark G., Davies, Donna E., Wang, Yihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252080/
https://www.ncbi.nlm.nih.gov/pubmed/30050057
http://dx.doi.org/10.1038/s41418-018-0175-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252080/
https://www.ncbi.nlm.nih.gov/pubmed/30050057
http://dx.doi.org/10.1038/s41418-018-0175-7

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