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1398. β-Lactam Probability of Target Attainment (PTA) and Penetration into Epithelial Lining Fluid (ELF) Based on Multiple Bronchoalveolar Lavage (BAL) Sampling Time Points in a Swine Pneumonia Model

BACKGROUND: Defining ELF concentrations is desired for antibiotics developed for pneumonia. For ethical reasons, BAL sampling in humans is routinely done at a single time point, thereby creating ambiguity in the precise ELF profile. It is unknown if additional sampling of the ELF would lead to more...

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Detalles Bibliográficos
Autores principales: Motos, Ana, Kuti, Joseph L, Bassi, Gianluigi Li, Torres, Antoni, Nicolau, David P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252810/
http://dx.doi.org/10.1093/ofid/ofy210.1229