1394. A Translational Pharmacokinetic Rat Model of Cerebral Spinal Fluid (CSF) and Plasma Concentrations of Cefepime

BACKGROUND: For treatment of central nervous system infections caused by GNB, adequate cefepime concentrations are required in the cerebral spinal fluid (CSF) and brain. However, high plasma cefepime exposures have resulted in neurotoxicity. There is a need to understand the real-time pharmacokineti...

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Detalles Bibliográficos
Autores principales: Liu, Jiajun, Avedissian, Sean, Pais, Gwendolyn, Joshi, Medha, Rhodes, Nathaniel J, Scheetz, Marc H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252923/
http://dx.doi.org/10.1093/ofid/ofy210.1225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252923/
http://dx.doi.org/10.1093/ofid/ofy210.1225

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