1421. IV Brincidofovir (BCV): Pharmacokinetics (PK) and Safety of Multiple Ascending Doses (MAD) in Healthy Subjects

BACKGROUND: BCV is a lipid conjugated nucleotide analog that has shown rapid viral clearance with oral administration in patients with adenovirus infection, and improved survival in animal models of smallpox. Phase I single ascending dose evaluation of IV BCV demonstrated that 2 hour infusions of 10...

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Detalles Bibliográficos
Autores principales: Naderer, Odin, Schuck, Virna, Morrison, Marion, Anderson, Maggie, Arumugham, Thangam, Dunn, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253859/
http://dx.doi.org/10.1093/ofid/ofy210.1252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253859/
http://dx.doi.org/10.1093/ofid/ofy210.1252

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