Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid

A series of etacrynic acid derivatives was synthesized and screened for their in vitro activity against Plasmodium falciparum, as well as their activity against recombinantly expressed falcipain-2 and -3. The two most active compounds of the series displayed IC(50) values of 9.0 and 18.8 μM against...

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Detalles Bibliográficos
Autores principales: Dude, Marie-Adrienne, Kaeppler, Ulrich, Herb, Monika, Schiller, Markus, Schulz, Franziska, Vedder, Birgit, Heppner, Saskia, Pradel, Gabriele, Gut, Jiri, Rosenthal, Philip J., Schirmeister, Tanja, Leippe, Matthias, Gelhaus, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253875/
https://www.ncbi.nlm.nih.gov/pubmed/19104483
http://dx.doi.org/10.3390/molecules14010019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253875/
https://www.ncbi.nlm.nih.gov/pubmed/19104483
http://dx.doi.org/10.3390/molecules14010019

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