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Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water
The three component reaction of primary aliphatic amines, glyoxalic acid and indole or N-methylindole in water at ambient temperature affords indol-3-yl or N-methylindol-3-yl-glycine in almost quantitative yields.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Molecular Diversity Preservation International
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253999/ https://www.ncbi.nlm.nih.gov/pubmed/19305359 http://dx.doi.org/10.3390/molecules14031056 |