Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water

The three component reaction of primary aliphatic amines, glyoxalic acid and indole or N-methylindole in water at ambient temperature affords indol-3-yl or N-methylindol-3-yl-glycine in almost quantitative yields.

Detalles Bibliográficos
Autores principales: Ghandi, Mehdi, Taheri, Abuzar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253999/
https://www.ncbi.nlm.nih.gov/pubmed/19305359
http://dx.doi.org/10.3390/molecules14031056
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author Ghandi, Mehdi
Taheri, Abuzar
author_facet Ghandi, Mehdi
Taheri, Abuzar
author_sort Ghandi, Mehdi
collection PubMed
description The three component reaction of primary aliphatic amines, glyoxalic acid and indole or N-methylindole in water at ambient temperature affords indol-3-yl or N-methylindol-3-yl-glycine in almost quantitative yields.
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spelling pubmed-62539992018-11-30 Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water Ghandi, Mehdi Taheri, Abuzar Molecules Article The three component reaction of primary aliphatic amines, glyoxalic acid and indole or N-methylindole in water at ambient temperature affords indol-3-yl or N-methylindol-3-yl-glycine in almost quantitative yields. Molecular Diversity Preservation International 2009-03-05 /pmc/articles/PMC6253999/ /pubmed/19305359 http://dx.doi.org/10.3390/molecules14031056 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ghandi, Mehdi
Taheri, Abuzar
Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water
title Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water
title_full Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water
title_fullStr Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water
title_full_unstemmed Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water
title_short Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water
title_sort efficient one-pot synthesis of indol-3-yl-glycines via uncatalyzed friedel-crafts reaction in water
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253999/
https://www.ncbi.nlm.nih.gov/pubmed/19305359
http://dx.doi.org/10.3390/molecules14031056
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