Cargando…

698. Nacubactam Inhibits Class A β-lactamases

BACKGROUND: Nacubactam, formerly RG6080 and OP0595 (Figure 1A), is a bridged diazabicyclooctane (DBO) that inactivates class A and class C β-lactamases. Unlike avibactam, the DBO that is approved for use in combination with ceftazidime, nacubactam also inhibits penicillin binding proteins (i.e., PBP...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barnes, Melissa D, Good, Caryn E, Bajaksouzian, Saralee, Taracila, Magdalena A, Duin, David Van, Kreiswirth, Barry N, Jacobs, Michael R, Papp-Wallace, Krisztina M, Bonomo, Robert A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254451/ http://dx.doi.org/10.1093/ofid/ofy210.705

Ejemplares similares

AAI101, a Novel β-Lactamase Inhibitor: Microbiological and Enzymatic Profiling
por: Papp-Wallace, Krisztina M, et al.
Publicado: (2017)

The Effectiveness of Imipenem–Relebactam against Ceftazidime-Avibactam Resistant Variants of the KPC-2 β-Lactamase
por: Papp-Wallace, Krisztina M., et al.
Publicado: (2023)

Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering
por: Barnes, Melissa D., et al.
Publicado: (2017)

Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent
por: Barnes, Melissa D., et al.
Publicado: (2019)

1437. Biochemical characterization of L1 and L2 β-lactamases from clinical isolates of Stenotrophomonas maltophilia
por: Mojica, Maria F, et al.
Publicado: (2020)

698. In vitro Activity of a New Generation Oxopyrazole Antibiotic Against Multidrug-Resistant Gram-Negative Bacilli
por: Goldberg, Joel, et al.
Publicado: (2019)

1351. In vitro Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, Against Enterobacteriaceae With Defined Extended-Spectrum Β-Lactamases and Carbapenemases
por: Jacobs, Michael R, et al.
Publicado: (2018)

Population Structure, Molecular Epidemiology, and β-Lactamase Diversity among Stenotrophomonas maltophilia Isolates in the United States
por: Mojica, Maria F., et al.
Publicado: (2019)

1250. Novel Boronic Acid Transition State Analogs (BATSI) with in vitro inhibitory activity against class A, B and C β-lactamases
por: Mojica, Maria F, et al.
Publicado: (2020)

Safety and Pharmacokinetic Characterization of Nacubactam, a Novel β-Lactamase Inhibitor, Alone and in Combination with Meropenem, in Healthy Volunteers
por: Mallalieu, Navita L., et al.
Publicado: (2020)

The Novel β-Lactamase Inhibitor, ETX-2514, in Combination with Sulbactam Effectively Inhibits Acinetobacter baumannii
por: Barnes, Melissa D, et al.
Publicado: (2017)

Bacterial Colonization and Antibiotic Resistance in a Prospective Cohort of Newborn Infants During the First Year of Life
por: Meropol, Sharon B., et al.
Publicado: (2016)

Novel β-lactamase inhibitors: a therapeutic hope against the scourge of multidrug resistance
por: Watkins, Richard R., et al.
Publicado: (2013)

1432. Exploring Cell Wall Targets to Overcome Mycobacterium tuberculosis (Mtb): Ceftriaxone (CRO) Inhibits Ldt(Mt2), a Major Peptidoglycan (PG) Synthase
por: Nguyen, David C, et al.
Publicado: (2022)

1279. In Vitro Activity of Nacubactam (OP0595) Alone and in Combination with β-Lactams against β-Lactamase-Producing Enterobacterales Isolated in Japan
por: Nagira, Yu, et al.
Publicado: (2020)

Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study
por: Krishnan, Nikhil P., et al.
Publicado: (2015)

The Class A β-Lactamase Produced by Burkholderia Species Compromises the Potency of Tebipenem against a Panel of Isolates from the United States
por: Becka, Scott A., et al.
Publicado: (2022)

Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in Pseudomonas aeruginosa
por: Barnes, Melissa D., et al.
Publicado: (2018)

1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of β-Lactamase Inhibitors against Acinetobacter baumannii Cephalosporinase
por: Caselli, Emilia, et al.
Publicado: (2020)

A comprehensive and contemporary “snapshot” of β-lactamases in carbapenem resistant Acinetobacter baumannii
por: Hujer, Andrea M., et al.
Publicado: (2021)

2806. The Mechanism of β-Lactam Antibiotic Action: Structural Analysis of Mycobacterium abscessus l,d-Transpeptidases, d,d-Carboxypeptidase and penicillin-binding-proteins binding by imipenem, ceftaroline, and amoxicillin
por: Shin, Eunjeong, et al.
Publicado: (2023)

Structures of FOX-4 Cephamycinase in Complex with Transition-State Analog Inhibitors
por: Lefurgy, Scott T., et al.
Publicado: (2020)

New Insights into Dissemination and Variation of the Health Care-Associated Pathogen Acinetobacter baumannii from Genomic Analysis
por: Wright, Meredith S., et al.
Publicado: (2014)

Erratum for “New Insights into Dissemination and Variation of the Health Care-Associated Pathogen Acinetobacter baumannii from Genomic Analysis”
por: Wright, Meredith S., et al.
Publicado: (2015)

FRI698 Hypoparathyroidism Secondary To Covid-19
por: Hussain, Mariam, et al.
Publicado: (2023)

Insights Into the Inhibition of MOX-1 β-Lactamase by S02030, a Boronic Acid Transition State Inhibitor
por: Ishikawa, Tatsuya, et al.
Publicado: (2021)

Inhibiting Mycobacterium abscessus Cell Wall Synthesis: Using a Novel Diazabicyclooctane β-Lactamase Inhibitor To Augment β-Lactam Action
por: Dousa, Khalid M., et al.
Publicado: (2022)

Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition
por: Hinchliffe, Philip, et al.
Publicado: (2022)

Editorial: Structural and Biochemical Aspects of the Interaction of β-Lactamases With State-of-the-Art Inhibitors
por: Papp-Wallace, Krisztina M., et al.
Publicado: (2022)

1348. In vitro Activity of Plazomicin, a Next-Generation Aminoglycoside, Against Carbapenemase-Producing Klebsiella pneumoniae
por: Jacobs, Michael R, et al.
Publicado: (2018)

1287. Pharmacokinetics, Safety, and Tolerability of Nacubactam after Single Coadministration with β-Lactams in Japanese Healthy Subjects
por: Asano, Masayo, et al.
Publicado: (2020)

Durlobactam, a Broad-Spectrum Serine β-lactamase Inhibitor, Restores Sulbactam Activity Against Acinetobacter Species
por: Papp-Wallace, Krisztina M, et al.
Publicado: (2023)

The Role of Hydrophobic Nodes in the Dynamics of Class A β-Lactamases
por: Olehnovics, Edgar, et al.
Publicado: (2021)

Installing and configuring Windows 10, 70-698 exam guide: learn to deploy, configure, and monitor Windows 10 effectively to prepare for the 70-698 exam
por: Dauti, Bekim
Publicado: (2019)

1359. Activity of Meropenem/Nacubactam Combination Against Gram-Negative Clinical Isolates: ROSCO Global Surveillance 2017
por: Okujava, Rusudan, et al.
Publicado: (2018)

Development of an optimized and practical pharmacokinetics/pharmacodynamics analysis method for aztreonam/nacubactam against carbapenemase-producing K. pneumoniae
por: Igarashi, Yuki, et al.
Publicado: (2023)

2136. In Vitro Activity of Nacubactam (OP0595) Combined with Cefepime against Carbapenem-resistant Enterobacterales Isolated in Japan
por: Yanagihara, Katsunori, et al.
Publicado: (2023)

Exam ref 70-698 installing and configuring Windows 10
por: Bettany, Andrew, et al.
Publicado: (2018)

Exam ref 70-698 installing and configuring Windows 10
por: Bettany, Andrew, et al.
Publicado: (2016)

MCSA Windows 10 study guide: exam 70-698
por: Panek, William
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_dn8lph6a5f483gu746aglsufta