Fasiglifam (TAK-875), a G Protein-Coupled Receptor 40 (GPR40) Agonist, May Induce Hepatotoxicity through Reactive Oxygen Species Generation in a GPR40-Dependent Manner

Fasiglifam (TAK-875) a G-protein coupled receptor 40 (GPR40) agonist, significantly improves hyperglycemia without hypoglycemia and weight gain, the major side effects of conventional anti-diabetics. Unfortunately, during multi-center Phase 3 clinical trials, unexpected liver toxicity resulted in pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, MinJeong, Gu, Gyo Jeong, Koh, Yun-Sook, Lee, Su-Hyun, Na, Yi Rang, Seok, Seung Hyeok, Lim, Kyung-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254646/
https://www.ncbi.nlm.nih.gov/pubmed/29429148
http://dx.doi.org/10.4062/biomolther.2017.225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254646/
https://www.ncbi.nlm.nih.gov/pubmed/29429148
http://dx.doi.org/10.4062/biomolther.2017.225

Ejemplares similares