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Attaining threshold antibody cytotoxicity for selective tumor cell destruction: an opinion article

We propose a novel immunotherapeutic paradigm that justifies application of several antibodies to various membrane-associated antigens to achieve a critical threshold density of immune complexes on the surface of cancer cells sufficient for triggering downstream cytolytic pathways. Indeed, some canc...

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Detalles Bibliográficos
Autores principales: Seledtsov, Victor I., Seledtsova, Galina V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254663/
https://www.ncbi.nlm.nih.gov/pubmed/30515270
http://dx.doi.org/10.18632/oncotarget.26271