Generation of 500-Member Library of 10-Alkyl-2-R(1),3-R(2)-4,10-DihydrobenzoDihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones

Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo Dihydrobenzo[4,5]imidazo[1,2-a]pyriminin-4-ones for their diversification by regioselective alkylation. Under the conditions established, the a...

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Detalles Bibliográficos
Autores principales: Sirko, Svetlana M., Gorobets, Nikolay Yu., Musatov, Vladimir I., Desenko, Sergey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254725/
https://www.ncbi.nlm.nih.gov/pubmed/20032888
http://dx.doi.org/10.3390/molecules14125223
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author Sirko, Svetlana M.
Gorobets, Nikolay Yu.
Musatov, Vladimir I.
Desenko, Sergey M.
author_facet Sirko, Svetlana M.
Gorobets, Nikolay Yu.
Musatov, Vladimir I.
Desenko, Sergey M.
author_sort Sirko, Svetlana M.
collection PubMed
description Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo Dihydrobenzo[4,5]imidazo[1,2-a]pyriminin-4-ones for their diversification by regioselective alkylation. Under the conditions established, the alkylation gave 10-alkyl derivatives which permitted the parallel generation of a 500-member library of the title compounds.
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spelling pubmed-62547252018-11-30 Generation of 500-Member Library of 10-Alkyl-2-R(1),3-R(2)-4,10-DihydrobenzoDihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones Sirko, Svetlana M. Gorobets, Nikolay Yu. Musatov, Vladimir I. Desenko, Sergey M. Molecules Article Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo Dihydrobenzo[4,5]imidazo[1,2-a]pyriminin-4-ones for their diversification by regioselective alkylation. Under the conditions established, the alkylation gave 10-alkyl derivatives which permitted the parallel generation of a 500-member library of the title compounds. Molecular Diversity Preservation International 2009-12-15 /pmc/articles/PMC6254725/ /pubmed/20032888 http://dx.doi.org/10.3390/molecules14125223 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Sirko, Svetlana M.
Gorobets, Nikolay Yu.
Musatov, Vladimir I.
Desenko, Sergey M.
Generation of 500-Member Library of 10-Alkyl-2-R(1),3-R(2)-4,10-DihydrobenzoDihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones
title Generation of 500-Member Library of 10-Alkyl-2-R(1),3-R(2)-4,10-DihydrobenzoDihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones
title_full Generation of 500-Member Library of 10-Alkyl-2-R(1),3-R(2)-4,10-DihydrobenzoDihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones
title_fullStr Generation of 500-Member Library of 10-Alkyl-2-R(1),3-R(2)-4,10-DihydrobenzoDihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones
title_full_unstemmed Generation of 500-Member Library of 10-Alkyl-2-R(1),3-R(2)-4,10-DihydrobenzoDihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones
title_short Generation of 500-Member Library of 10-Alkyl-2-R(1),3-R(2)-4,10-DihydrobenzoDihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones
title_sort generation of 500-member library of 10-alkyl-2-r(1),3-r(2)-4,10-dihydrobenzodihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254725/
https://www.ncbi.nlm.nih.gov/pubmed/20032888
http://dx.doi.org/10.3390/molecules14125223
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