Soft Alkyl Ether Prodrugs of a Model Phenolic Drug: The Effect of Incorporation of Ethyleneoxy Groups on Transdermal Delivery

Two different types of soft alkyl ether prodrugs incorporating ethyleneoxy groups into the promoiety have been synthesized for a model phenol (acetaminophen, APAP): alkyloxycarbonyloxymethyl type (AOCOM) and N-alkyl-N-alkyloxycarbonyl-aminomethyl type (NANAOCAM). The solubilities in isopropyl myrist...

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Detalles Bibliográficos
Autores principales: Thomas, Joshua Denver, Majumdar, Susruta, Sloan, Kenneth Berry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254794/
https://www.ncbi.nlm.nih.gov/pubmed/19924060
http://dx.doi.org/10.3390/molecules14104231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254794/
https://www.ncbi.nlm.nih.gov/pubmed/19924060
http://dx.doi.org/10.3390/molecules14104231

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