Development of a High-Throughput Assay for Screening of γ-Secretase Inhibitor with Endogenous Human, Mouse or Drosophila γ-Secretase

Selective lowering of amyloid-β levels with small-molecule γ-secretase inhibitors is a promising therapeutic approach for Alzheimer’s disease. In this work, we developed a high throughput assay for screening of γ-secretase inhibitors with endogenous γ-secretase and a fluorogenic substrate. The IC(50...

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Detalles Bibliográficos
Autores principales: Wang, Lie-Feng, Zhang, Ru, Xie, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254802/
https://www.ncbi.nlm.nih.gov/pubmed/19783945
http://dx.doi.org/10.3390/molecules14093589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254802/
https://www.ncbi.nlm.nih.gov/pubmed/19783945
http://dx.doi.org/10.3390/molecules14093589

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