Solid-Phase Synthesis of Optically Active Substituted 2-Aminofuranones Using an Activated Carbonate Linker

An efficient three-step solid-phase synthesis of diverse 3,5-disubstituted-2-aminofuranones has been developed. α-Hydroxy acids loaded on a nitrophenyl carbonate derivative of Wang resin are used as acylating agents for the C-acylation of active methylene compounds and the resulting intermediates pr...

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Autores principales: Matiadis, Dimitris, Prousis, Kyriakos C., Igglessi-Markopoulou, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254804/
https://www.ncbi.nlm.nih.gov/pubmed/19924038
http://dx.doi.org/10.3390/molecules14103914
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author Matiadis, Dimitris
Prousis, Kyriakos C.
Igglessi-Markopoulou, Olga
author_facet Matiadis, Dimitris
Prousis, Kyriakos C.
Igglessi-Markopoulou, Olga
author_sort Matiadis, Dimitris
collection PubMed
description An efficient three-step solid-phase synthesis of diverse 3,5-disubstituted-2-aminofuranones has been developed. α-Hydroxy acids loaded on a nitrophenyl carbonate derivative of Wang resin are used as acylating agents for the C-acylation of active methylene compounds and the resulting intermediates provided, through a cyclative cleavage reaction, the desired product.
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spelling pubmed-62548042018-11-30 Solid-Phase Synthesis of Optically Active Substituted 2-Aminofuranones Using an Activated Carbonate Linker Matiadis, Dimitris Prousis, Kyriakos C. Igglessi-Markopoulou, Olga Molecules Article An efficient three-step solid-phase synthesis of diverse 3,5-disubstituted-2-aminofuranones has been developed. α-Hydroxy acids loaded on a nitrophenyl carbonate derivative of Wang resin are used as acylating agents for the C-acylation of active methylene compounds and the resulting intermediates provided, through a cyclative cleavage reaction, the desired product. Molecular Diversity Preservation International 2009-09-30 /pmc/articles/PMC6254804/ /pubmed/19924038 http://dx.doi.org/10.3390/molecules14103914 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Matiadis, Dimitris
Prousis, Kyriakos C.
Igglessi-Markopoulou, Olga
Solid-Phase Synthesis of Optically Active Substituted 2-Aminofuranones Using an Activated Carbonate Linker
title Solid-Phase Synthesis of Optically Active Substituted 2-Aminofuranones Using an Activated Carbonate Linker
title_full Solid-Phase Synthesis of Optically Active Substituted 2-Aminofuranones Using an Activated Carbonate Linker
title_fullStr Solid-Phase Synthesis of Optically Active Substituted 2-Aminofuranones Using an Activated Carbonate Linker
title_full_unstemmed Solid-Phase Synthesis of Optically Active Substituted 2-Aminofuranones Using an Activated Carbonate Linker
title_short Solid-Phase Synthesis of Optically Active Substituted 2-Aminofuranones Using an Activated Carbonate Linker
title_sort solid-phase synthesis of optically active substituted 2-aminofuranones using an activated carbonate linker
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254804/
https://www.ncbi.nlm.nih.gov/pubmed/19924038
http://dx.doi.org/10.3390/molecules14103914
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AT igglessimarkopoulouolga solidphasesynthesisofopticallyactivesubstituted2aminofuranonesusinganactivatedcarbonatelinker

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